Windows – Kill unresponsive process in windows that won’t stop through Task Manager or Process Explorer

Up front: I'm using windows 7 64 bit.

So sometimes I am trying to kill a process but it won't quit. I can try killing the process or the process structure, but Task Manager won't accomplish anything. There are a couple of tricks on the net, like

taskkill.exe /f /fi "status eq not responding"

but I wouldn't be asking here if that did the job…

Is there any trick to get rid of these processes completely?

The reason I'm dealing with this is because I sometimes run a program that won't start properly and starts a bunch of helper programs, but none of the helper programs show up the processes, so I figured that just killing the processes that are visibly active would do the trick, though seemingly they are jammed.

Thanks to a few users I have tried resolving the issue by using Process Explorer and closing the handle/killing the process. This did not work either. If you have any other suggestions I'll be happy to hear them.