I have an issue using the following versions
Chrome 65.0.3325.181 (Official Build) (64-bit)
MacOS Sierra 10.12.6
When I open a new tab, sometimes all my bluetooth devices (headphones, mouse, keyboard) become disconnected. They come back in ~5 minutes, resetting devices or the bluetooth module doesn't help
Best Answer
The issue was in the voice search ("OK Google")
When a user opens a new tab, Chrome sometimes tries to access microphone to use voice search which breaks bluetooth connectivity.
Resolution:
Go to chrome://flags/ and disable option "Enable Voice Search on the local NTP"