Windows – Keyboard shortcut to open PowerShell from the Desktop

Click Change preferences in the search sidebar, then Change files and folders search behavior, choose Advanced then click OK.

First, create a shortcut to your Desktop. i.e. C:\Users\%username%\Desktop

Then see here on how to assign it a shortcut key, maybe CTRL ALT D or something?

• Locate the shortcut to the program that you want to create a keyboard shortcut for.
• Right-click the shortcut, and then click Properties.
• In the Shortcut Properties dialog box, click the Shortcut tab.
• Click in the Shortcut key box, press the key on your keyboard that you want to use in combination with Ctrl+Alt (keyboard shortcuts automatically start with Ctrl+Alt), and then click OK. If you're prompted for an administrator password or confirmation, type the password or provide confirmation.