Windows – How to open a URL in a new browser window with AutoHotkey

I would try using context-sensitive hotkeys instead of checking the active window on keypress. Your other hotkeys still work the same, but since your browsers are not specified, they will maintain their normal functionality. I created your desired functionality by using the code below:

#IfWinActive ahk_class ATH_Note
  ^w::Send !{F4}
#IfWinActive

#IfWinActive ahk_class Notepad
  ^w::Send !{F4}
#IfWinActive

#IfWinActive ahk_class Outlook Express Browser Class
  ^w::WinMinimize, A
#IfWinActive

#IfWinActive ahk_class IrfanView
  ^w::Esc
#IfWinActive

If there are some shared hotkeys between programs, you can also create groups:

GroupAdd, FileExplorer, ahk_class EVERYTHING
GroupAdd, FileExplorer, ahk_class CabinetWClass
GroupAdd, FileExplorer, ahk_class #32770

#IfWinActive ahk_group FileExplorer
    ^w::WinMinimize, A
#IfWinActive

Most likely WInactivate does not work because you need to add SetTitleMatchMode, 2 at the top of your script. To test if WinActivate really works use this:

SetTitleMatchMode, 2
#c::
Run "C:\Program Files (x86)\Google\Chrome\Application\chrome.exe" -start-maximized --new-window www.google.com
WinWait, google ;Give Chrome a chance to start before testing
IfWinExist, google
{
    WinActivate, google ; Window title is "Google"
    MessageBox, OK
}
Return

If you do NOT see the OK message, your Winactivate still waits for the correct title. Once you are sure this works, you can reduce is back to:

SetTitleMatchMode, 2
#c::
Run "C:\Program Files (x86)\Google\Chrome\Application\chrome.exe" -start-maximized --new-window www.google.com
WinWait, google ;Give Chrome a chance to start before testing
WinActivate, google ; Window title is "Google"
Return