Mouse left and right click buttons unresponsive for periods of time seemly at random.
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Mouse tried: wired, wireless, wireless, Bluetooth, surface typecover cover touchpad and all possible combinations at the same time. Left and right click will be locked for periods of time. Persists through restarts. Persists through unplugging/replugging all mouse type device.
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Mouse scrolling and cursor movement is not affects (just right and left click does not work). Keyboard works. Touchscreen works.
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Sometimes mouse click works on taskbar, but not on any foreground applications.
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The only fix known so far is by starting an application called X-Mouse Button Control. It is able to "unlock" my mouse buttons. Before finding this solution, I needed to restart multiple times.
Best Answer
The solution to the problem is found!
It turns out the problem was mouse 'Button 4' in one of my mouse may spontaneously activate and stay activated. This introduces the observed behavior where it seems like left and right mouse buttons are disabled for all currently connected mouse and mouse connected in the future. The behavior which made the problem worse is the 'Mouse button 4' stays activated even if mouse wireless adapter is disconnected! Mouse button 4 also stays activated across reboots if the wireless mouse adapter is not disconnected during reboot. That's why we observed problem symptoms across reboots and disconnect/reconnect of a range of mouse.
The solution is to explicitly disable 'Button 4' through software for the semi-broken or all mouse. The easiest solution is to use a free program called X-Mouse Button Control. Autohotkey script to disable 'Button 4' should also work well.