uBlock Origin certainly has hotkeys, as I've invoked the program accidentally by pressing keys and the developer has participated in a related discussion on the Github page.
In particular a hotkey for the element picker would improve workflow as I already have thousands of cosmetic and network filters.
Best Answer
For Chromium or Chrome:
Now you can add custom shortcut from extensions page.
Go to:
Menu -> More Tools -> Extensions
.Click on left menu button and
Keyboard Shortcuts
.Find
uBlock
and assign your shortcut like below screenshot: