Mac OS X DNS lookups take forever from Safari and other applications that use mDNSResponder. The same lookups work fine if I use nslookup from the command line, and they also work fine from my iPhone and iPad on the same wireless network.
And that's only on the network at work; when I'm at home, or tethered to my iPhone, all DNS lookups work fine. When I'm on the network at work, either via Wi-Fi or Ethernet, I have these problems. I've tried using the following commands:
launchctl unload /System/Library/LaunchDaemons/com.apple.mDNSResponder.plist
launchctl load /System/Library/LaunchDaemons/com.apple.mDNSResponder.plist
That used to provide some temporary relief (minutes) under Snow Leopard, but now, under Lion, it usually doesn't provide anything at all.
Neither my Ethernet nor Wi-Fi settings specify DNS servers; they're auto-filled from the router. But I have tried specifying my own, like Google DNS or OpenDNS, and that doesn't fix the problem.
The network setup is a router plugged into the cable modem, with all Ethernet ports in the office coming off of it. An Airport Extreme wifi router is also plugged into the main router (in bridge mode), and the WiFi clients connect to that.
I've searched all over and found other things that look applicable at first (e.g. DNS lookup fails but nslookup works), making me think that these mDNSResponder issues aren't too uncommon, but none of them exactly match and their solutions haven't worked for me yet.
Also: it's not every DNS lookup, just most. Google searches come up instantly, but Google Maps takes forever to load (when I look at the activity window, it's usually scripts and whatnot coming from some Google CDN server). Even sites that we use every day, and you'd think would be cached someplace (like php.net) take forever to load, or time out.
Also: everything loads fine from a browser within a Windows XP virtual machine, which to me points even more accusingly at mDNSResponder as the culprit – but everything works fine when I'm any other network.
Best Answer
The reason for DNS being slow at the office but not at home, might be that the office router uses IPv6 but your home router uses IPv4, and that Lion is better on using IPv6 than Snow Leopard. The websites that are not affected by that slowdown are then probably the ones that have better support for IPv6.
See this article for measures that show IPv6 to be 2-3 times slower than IPv4 on DNS :
IPv6 Will Slow You Down (DNS)
If that's the case, disabling IPv6 on the office router (and so on the entire office network) might solve the problem.
This article might also be useful : How to Disable IPv6 on Mac OS X 10.7 Lion.