OPTION 1 - Block it yourself
Go to a site, get a popup.
Click the AdBlock extension button on the toolbar, and select "Block an ad on this page"
Show it the ad, and it get the following window:
The id and name elements, while containing the text google_ads also contain data specific to this page. To make this blocking rule more general, I unticked those, leaving type and class, because IFRAMEs are hardly used any more, and one that is supposed to actively hide is pretty suspicious.
We'll see how that goes in the future. It should filter a few ads at least.
OPTION 2 - Edit your own rules
You can go into the AdBlock Customise tab, and manually edit your filters.
You'll see the ad we blocked in Option 1 (if you tried it) as:
www.wired.com##IFRAME[class="active hide-mob"]
We can make it more general using the google_ads text we saw earlier, and remove the limitation to Wired (note the * to make the text match less specific):
*##IFRAME[id*="google_ads"]
OPTION 3 - Let someone else block it
Click on the AdBlock button in your tool bar, and go to options. There is a list of filters currently applied. One that is not ticked by default is described as:
Fanboy's Annoyances (blocks in-page pop-ups, social media and related widgets, and other annoyances)
Try turning this on and see if it helps
You can disable these prompts from your Google account's permissions page:
https://myaccount.google.com/permissions
Or go into your Google Account Settings and to the Security Tab. Here you will find a section "Signing in to other sites". Select the "Signing in with Google" link to get to your permissions site.
Google Account sign-in prompts
Allow Google to offer a faster way to sign in with your Google Account on supported third-party sites
Toggle off "Google Account sign-in prompts" to disable these prompts across the web.
Don't be fooled by the toggle since it currently doesn't seem to display the toggle state correctly. Click it once and refresh.
Best Answer
Your extensions are modifying webpages to be different than the pages developer intended. Adblock and Adblock Plus remove elements and block scripts which are many times essential for webpages to work correctly. You see this a lot on video websites where disabling or allowing certain scripts allows videos to play correctly.
I would use one adblocker since running Adblock and Adblock Plus at the same time is redundant. Keep your trackers up to date to reduce issues due to website changes.
As for hardware, some mice have settings you can tweak within the operating system and even per application so middle click might open a new tab in Chrome but prompt a print dialogue in another browser. Something like that.
To understand the software side, if I make a website and the footer has an ad and your ad blocker removes the entire footer, my webpage could break because scripts rely on the footer to run, scripts are loaded in the footer, or something as simple as the webpage no longer displays correctly because there is no defined bottom of the page.