Computer is Really Slow – Troubleshooting Tips

The disk activity is on the pagefile. You need more RAM.

Note that the Winzip memory optimiser is using more the 25% of the RAM. I'd get rid of that and any similar utilities before you investigate further.

First, don't install so much anti-malware to get rid of the malware you have.

MalwareBytes is one of the best apps for this; especially for people who don't know how to manage their own computers. Here's a nice How To if you need help learning how to use it. (Update: Also, malwarebytes is extremely lightweight and free for home users. The difference between the free and paid version is the paid version will actively monitor your system and protect, whereas the free version will only scan your system when you tell it to; in short, proactive verses reactive protection)

Second, your computer is hosed. The registry is probably corrupt from all the malware and or bad attempts to install legitimate patches. This happens from time to time, either due to a bad order of installations for the patches or because it's patch Tuesday and it's Microsoft. It happens way more than it should (it should never happen, but it does, because it's Microsoft). This is preventing you from installing that service pack or patch that you want (also, to the guy who says SP2 is available; no, it's not--not officially anyway, and probably never, according to a quick Google search).

You're better off backing up your data to a USB hard drive, formatting your system and starting from scratch. It'll save you time and headaches, as rebuilding a PC can take 2-4 hours, whereas constantly troubleshooting malware and registry issues can go on forever.