media playervlc-media-player
Are there any expert configuration guides for tweaking the best out of VLC Media Player?
I know that there is the documentation but I'm looking for a guide that takes you through the most important settings of the configuration to tweak it up a little, like those that you can find on tweakguides.com
On a Linux system, there is a file $HOME/.config/vlc/vlc-qt-interface.conf which contains the entry named [RecentsMRL], which contains the recent history.
To use VLC to browse UPnP servers like MediaTomb, you must turn on the Universal Plug n Play Services Discovery module. To do so, open VLC, go to Tools and Preferences, select All under Show settings, open Playlist, select Services discovery, and check Universal Plug'n'Play. Then, click Save and exit VLC.
Now you can reopen VLC. To browse UPnP servers, click the 
Playlist button, open Local Network in the left pane, and choose Universal Plug'n'Play.
Best Answer
VLC is very complex video player with lots of options. The entire video decoding and display process is extremely complicated. Many times tweaks can be made to enhance performance, however most of the time these tweaks are specific to a specific media file or format. It would be extremely difficult to put together a guide on how to tweak it without being specific to a single format.
IMHO the folks at VLC have done a great job at providing reasonable defaults that perform quite well. If there is some specific aspect of VLC you are looking to tweak, please include it in your question, otherwise, if the defaults aren't cutting it, the VLC documentation is probably the best place to start: