Mysql – How to find the stored binary value of a DOUBLE value in MySQL

As DTest pointed out, provide more information about your problem.

Regarding caching, you could possibly increase your innodb buffer pool size to allow more data and indexes to be cached in memory. If you have frequent updates, you may not benefit from the query cache and might be better off using that RAM for innodb buffer pool.

If you want to put all your data and indexes in RAM, then MySQL Cluster might be your answer.

EDIT
It looks like your SELECT statements are using proper indexes. Could you provide an explain plan for your update statement? You will have to rewrite it as a SELECT statement to do that. Do a SELECT * FROM same table and with same where clause as your UPDATE statement.

I am not very familiar with your needs, but perhaps storing each data point in the database is a bit of overkill. It sound almost like taking the approach of storing an image library by storing each pixel as a separate record in a relational database.

As a general rule, storing binary data in databases is wrong most of the time. There is usually a better way of solving the problem. While it is not inherently wrong to store binary data in relational database, often times the disadvantages outweigh the gains. Relational databases, as the name alludes to, are best suited for storing relational data. Binary data is not relational. It adds size (often significantly) to databases, can hurt performance, and may lead to questions about maintaining billion-record MySQL instances. The good news is that there are databases especially well suited for storing binary data. One of them, while not always readily apparent, is your file system! Simply come up with a directory and file naming structure for your binary files, store those in your MySQL DB together with any other data which may yield value through querying.

Another approach would be using a document-based storage system for your datapoints (and perhaps spectra) data, and using MySQL for the runs (or perhaps putting the runs into the same DB as the others).