Sql-server – SQL Server 2008 R2 – Set tempDB size on full disk

You should be aiming to auto-grow as little as possible. Seven times a day is excruciating, even with instant file initialization.

Don't do a Shrink Database. Ever. Shrinkfile, maybe, but only after an extraordinary event. Shrinking it just to grow again is an exercise in futility and should actually be called auto-fragment.

If recovery model is simple, there is no way on earth you should need to grow your log file by 250 GB. The used space in the file will clean itself out automatically over time, unless you started a transaction a month ago and have no intentions of ever committing it or rolling it back.

So my advice would be:

Auto-grow the data file manually during a quiet period to a size that will accommodate several months of growth. What are you saving it for in the meantime?

Set the auto-growth increment for the data file to something relatively small (so that it doesn't interrupt users when it does happen), and alert on this event (you can catch it in the default trace, for example, or through extended events). This can tell you that you are hitting the high point you estimated and it is time to grow manually again. At this point you will want to keep this manual in case you want to add a new file / filegroup on a different drive to accommodate the space, since eventually you will fill the current drive.

Auto-grow the log file to, say, twice the largest it's ever been. It shouldn't auto-grow further unless there is some abnormal transaction holding things up. You should monitor for this event as well, so that you know about them.

^{(Note: this isn't a 100% certain answer, and I don't have references, so let me know if you can prove otherwise.)}

The version store can only clear versions based on the oldest active transaction within the entire instance, to support the use of transaction-level snapshot isolation across multiple databases simultaneously. That simply wouldn't work if "old" versions within one database were cleared out in the middle of another database's snapshot transaction.

So, if there's a very old open transaction, the version store will not be able to clear until that transaction either commits or rolls back.