If you're on *nix - check out the tools sed, awk, grep and split and related (or even vi). As mentioned perl could do it, so could python or PHP (or C or Java or ...) This looks more like a task for programming tools rather than a database. That's not to say you couldn't do this using PL/SQL or T-SQL or , but sometimes the most suitable tool is not within the database server (and in this case, certainly not within MySQL).

Convert the first value using user variables to load the True/False values.

Then, compare it to the value 'True'

PROPOSED SOLUTION

LOAD DATA LOCAL INFILE 'C:/bin/input.txt' INTO TABLE n1
FIELDS TERMINATED BY ',' ENCLOSED BY '\"'
LINES TERMINATED BY '\r\n' (@var1,c2)
SET c1 = (@var1 = 'True');

SAMPLE DATA

C:\bin>dir
 Volume in drive C is TI10665200H
 Volume Serial Number is A273-2EFF

 Directory of C:\bin

10/21/2014  10:01 AM    <DIR>          .
10/21/2014  10:01 AM    <DIR>          ..
10/21/2014  10:01 AM                23 input.txt
               1 File(s)             23 bytes
               2 Dir(s)  685,548,244,992 bytes free

C:\bin>type input.txt
"False","1"
"True","2"
C:\bin>

CODE FOR PROPOSED SOLUTION

USE test
DROP TABLE IF EXISTS n1;
CREATE TABLE `n1` (
  `c1` boolean ,
  `c2` int
) ENGINE=InnoDB DEFAULT CHARSET=latin1;
LOAD DATA LOCAL INFILE 'C:/bin/input.txt' INTO TABLE n1
FIELDS TERMINATED BY ',' ENCLOSED BY '\"'
LINES TERMINATED BY '\r\n' (@var1,c2)
SET c1 = (@var1 = 'True');
SELECT * FROM n1;

CODE FOR PROPOSED SOLUTION EXECUTED

mysql> USE test
Database changed
mysql> DROP TABLE IF EXISTS n1;
Query OK, 0 rows affected (0.14 sec)

mysql> CREATE TABLE `n1` (
    ->   `c1` boolean ,
    ->   `c2` int
    -> ) ENGINE=InnoDB DEFAULT CHARSET=latin1;
Query OK, 0 rows affected (0.38 sec)

mysql> LOAD DATA LOCAL INFILE 'C:/bin/input.txt' INTO TABLE n1
    -> FIELDS TERMINATED BY ',' ENCLOSED BY '\"'
    -> LINES TERMINATED BY '\r\n' (@var1,c2)
    -> SET c1 = (@var1 = 'True');
Query OK, 2 rows affected (0.03 sec)
Records: 2  Deleted: 0  Skipped: 0  Warnings: 0

mysql> SELECT * FROM n1;
+------+------+
| c1   | c2   |
+------+------+
|    0 |    1 |
|    1 |    2 |
+------+------+
2 rows in set (0.00 sec)

mysql>

GIVE IT A TRY !!!