Mysql – Are these stats reasonable? If not, where should I start

The below is the output result of mysqladmin for our mysql server which has been having consistent problems for months since we switched from a dedicated server to the cloud. In the switch, we changed some tuning parameters, and it seems possible that one of these parameters was messed up. I'm the defacto DBA, but don't know much. I'm trying to figure out how to interpret the below:

Server version      5.7.23-0ubuntu0.16.04.1-log
Uptime:         117 days 22 hours 28 min 44 sec

Threads: 29  Questions: 1969788526  Slow queries: 143857  Opens: 11865506181  Flush tables: 1  Open tables: 512  Queries per second avg: 193.311

+————————————————+——–

| Aborted_clients | 416
| Aborted_connects | 1639
| Binlog_cache_disk_use | 71808
| Binlog_cache_use | 21395190
| Binlog_stmt_cache_disk_use | 0
| Binlog_stmt_cache_use | 93
| Bytes_received | 1354770670850
| Bytes_sent | 3602027204751
| Com_admin_commands | 13164
| Com_assign_to_keycache | 0
| Com_alter_table | 71
| Com_analyze | 1
| Com_begin | 12066261
| Com_binlog | 0
| Com_change_db | 137117
| Com_commit | 22424711
| Com_create_table | 2
| Com_create_trigger | 0
| Com_create_udf | 0
| Com_create_user | 1
| Com_create_view | 0
| Com_dealloc_sql | 70
| Com_delete | 277919
| Com_delete_multi | 0
| Com_do | 0
| Com_drop_db | 0
| Com_drop_event | 0
| Com_drop_function | 0
| Com_drop_index | 0
| Com_drop_procedure | 0
| Com_drop_server | 0
| Com_drop_table | 0
| Com_drop_trigger | 0
| Com_drop_user | 0
| Com_drop_view | 0
| Com_empty_query | 0
| Com_execute_sql | 74
| Com_explain_other | 0
| Com_flush | 119
| Com_get_diagnostics | 0
| Com_grant | 3
| Com_ha_close | 0
| Com_ha_open | 0
| Com_ha_read | 0
| Com_help | 0
| Com_insert | 105344680
| Com_insert_select | 259735
| Com_install_plugin | 0
| Com_kill | 8
| Com_load | 0
| Com_lock_tables | 6
| Com_optimize | 0
| Com_preload_keys | 0
| Com_prepare_sql | 74
| Com_purge | 0
| Com_purge_before_date | 0
| Com_release_savepoint | 0
| Com_rename_table | 0
| Com_rename_user | 0
| Com_repair | 0
| Com_replace | 1
| Com_replace_select | 0
| Com_reset | 0
| Com_resignal | 0
| Com_revoke | 0
| Com_revoke_all | 0
| Com_rollback | 28394
| Com_rollback_to_savepoint | 0
| Com_savepoint | 0
| Com_select | 1502927854
| Com_set_option | 50365426
| Com_signal | 0
| Com_show_binlog_events | 0
| Com_show_binlogs | 4
| Com_show_charsets | 7149
| Com_show_collations | 7149
| Com_show_create_table | 101370273
| Com_show_create_trigger | 0
| Com_show_databases | 8
| Com_show_engine_logs | 0
| Com_show_engine_mutex | 0
| Com_show_engine_status | 27
| Com_show_events | 0
| Com_show_errors | 0
| Com_show_fields | 101370995
| Com_show_function_code | 0
| Com_show_function_status | 0
| Com_show_grants | 4
| Com_show_keys | 589
| Com_show_master_status | 2
| Com_show_open_tables | 0
| Com_show_plugins | 0
| Com_show_privileges | 0
| Com_show_procedure_code | 0
| Com_show_procedure_status | 0
| Com_show_processlist | 5
| Com_show_profile | 0
| Com_show_profiles | 0
| Com_show_relaylog_events | 0
| Com_show_slave_hosts | 4
| Com_show_slave_status | 6
| Com_show_status | 38
| Com_show_storage_engines | 4
| Com_show_table_status | 136
| Com_show_tables | 88
| Com_show_triggers | 116
| Com_show_variables | 7287
| Com_show_warnings | 8047
| Com_show_create_user | 0
| Com_shutdown | 0
| Com_group_replication_start | 0
| Com_group_replication_stop | 0
| Com_stmt_execute | 74
| Com_stmt_close | 72
| Com_stmt_fetch | 0
| Com_stmt_prepare | 74
| Com_stmt_reset | 0
| Com_stmt_send_long_data | 0
| Com_truncate | 0
| Com_uninstall_plugin | 0
| Com_unlock_tables | 6
| Com_update | 57786921
| Com_update_multi | 0
| Com_xa_commit | 0
| Com_xa_end | 0
| Com_xa_prepare | 0
| Com_xa_recover | 0
| Com_xa_rollback | 0
| Com_xa_start | 0
| Com_stmt_reprepare | 0
| Compression | OFF
| Connections | 29435898
| Created_tmp_disk_tables | 114402068
| Created_tmp_files | 38275
| Created_tmp_tables | 2504646759
| Delayed_errors | 0
| Delayed_insert_threads | 0
| Delayed_writes | 0
| Flush_commands | 1
| Handler_commit | 1757942766
| Handler_delete | 52633379
| Handler_discover | 0
| Handler_external_lock | 27091706448
| Handler_mrr_init | 0
| Handler_prepare | 342205456
| Handler_read_first | 4803251242
| Handler_read_key | 4225308943902
| Handler_read_last | 40865194
| Handler_read_next | 6485209270841
| Handler_read_prev | 10366415789
| Handler_read_rnd | 171538509
| Handler_read_rnd_next | 3848495865600
| Handler_rollback | 48600
| Handler_savepoint | 0
| Handler_savepoint_rollback | 0
| Handler_update | 87510208
| Handler_write | 1055828705804
| Innodb_buffer_pool_dump_status | Dumping of buffer pool
not started |

| Innodb_buffer_pool_load_status | Buffer pool(s) load
completed at 181025 2:58:45 |

| Innodb_buffer_pool_resize_status |
| Innodb_buffer_pool_pages_data | 313229
| Innodb_buffer_pool_bytes_data | 5131943936
| Innodb_buffer_pool_pages_dirty | 978
| Innodb_buffer_pool_bytes_dirty | 16023552
| Innodb_buffer_pool_pages_flushed | 8590250
| Innodb_buffer_pool_pages_free | 8262
| Innodb_buffer_pool_pages_misc | 6149
| Innodb_buffer_pool_pages_total | 327640
| Innodb_buffer_pool_read_ahead_rnd | 0
| Innodb_buffer_pool_read_ahead | 303530
| Innodb_buffer_pool_read_ahead_evicted | 0
| Innodb_buffer_pool_read_requests | 26856935971072
| Innodb_buffer_pool_reads | 304296
| Innodb_buffer_pool_wait_free | 0
| Innodb_buffer_pool_write_requests | 4292568734
| Innodb_data_fsyncs | 31123982
| Innodb_data_pending_fsyncs | 0
| Innodb_data_pending_reads | 0
| Innodb_data_pending_writes | 0
| Innodb_data_read | 10002846208
| Innodb_data_reads | 610655
| Innodb_data_writes | 38339619
| Innodb_data_written | 397157095424
| Innodb_dblwr_pages_written | 8390289
| Innodb_dblwr_writes | 543675
| Innodb_log_waits | 0
| Innodb_log_write_requests | 196703019
| Innodb_log_writes | 29155331
| Innodb_os_log_fsyncs | 29182283
| Innodb_os_log_pending_fsyncs | 0
| Innodb_os_log_pending_writes | 0
| Innodb_os_log_written | 118934181888
| Innodb_page_size | 16384
| Innodb_pages_created | 382512
| Innodb_pages_read | 610519
| Innodb_pages_written | 8590462
| Innodb_row_lock_current_waits | 0
| Innodb_row_lock_time | 7111105
| Innodb_row_lock_time_avg | 4320
| Innodb_row_lock_time_max | 51061
| Innodb_row_lock_waits | 1646
| Innodb_rows_deleted | 52633379
| Innodb_rows_inserted | 2211335475
| Innodb_rows_read | 12988670090784
| Innodb_rows_updated | 62207650
| Innodb_num_open_files | 127
| Innodb_truncated_status_writes | 0
| Innodb_available_undo_logs | 128
| Key_blocks_not_flushed | 0
| Key_blocks_unused | 53585
| Key_blocks_used | 8
| Key_read_requests | 2077
| Key_reads | 184
| Key_write_requests | 684
| Key_writes | 20
| Last_query_cost | 0.000000
| Last_query_partial_plans | 0
| Locked_connects | 0
| Max_execution_time_exceeded | 0
| Max_execution_time_set | 0
| Max_execution_time_set_failed | 0
| Max_used_connections | 37
| Max_used_connections_time | 2018-11-27 20:52:01
| Not_flushed_delayed_rows | 0
| Ongoing_anonymous_transaction_count | 0
| Open_files | 3
| Open_streams | 0
| Open_table_definitions | 343
| Open_tables | 512
| Opened_files | 859373
| Opened_table_definitions | 488
| Opened_tables | 11867165737
| Performance_schema_accounts_lost | 0
| Performance_schema_cond_classes_lost | 0
| Performance_schema_cond_instances_lost | 0
| Performance_schema_digest_lost | 0
| Performance_schema_file_classes_lost | 0
| Performance_schema_file_handles_lost | 0
| Performance_schema_file_instances_lost | 63
| Performance_schema_hosts_lost | 0
| Performance_schema_index_stat_lost | 0
| Performance_schema_locker_lost | 0
| Performance_schema_memory_classes_lost | 0
| Performance_schema_metadata_lock_lost | 0
| Performance_schema_mutex_classes_lost | 0
| Performance_schema_mutex_instances_lost | 0
| Performance_schema_nested_statement_lost | 0
| Performance_schema_prepared_statements_lost | 0
| Performance_schema_program_lost | 0
| Performance_schema_rwlock_classes_lost | 0
| Performance_schema_rwlock_instances_lost | 0
| Performance_schema_session_connect_attrs_lost | 0
| Performance_schema_socket_classes_lost | 0
| Performance_schema_socket_instances_lost | 0
| Performance_schema_stage_classes_lost | 0
| Performance_schema_statement_classes_lost | 0
| Performance_schema_table_handles_lost | 0
| Performance_schema_table_instances_lost | 0
| Performance_schema_table_lock_stat_lost | 0
| Performance_schema_thread_classes_lost | 0
| Performance_schema_thread_instances_lost | 0
| Performance_schema_users_lost | 0
| Prepared_stmt_count | 0
| Qcache_not_cached | 26282360
| Queries | 1983838412
| Questions | 1983825241
| Select_full_join | 2510
| Select_full_range_join | 0
| Select_range | 133055836
| Select_range_check | 0
| Select_scan | 4834557364
| Slow_launch_threads | 0
| Slow_queries | 144451
| Sort_merge_passes | 8779
| Sort_range | 5238452
| Sort_rows | 344471904
| Sort_scan | 24075234
| Table_locks_immediate | 11412632
| Table_locks_waited | 0
| Table_open_cache_hits | 1881438893
| Table_open_cache_misses | 11867165733
| Table_open_cache_overflows | 11867164202
| Tc_log_max_pages_used | 0
| Tc_log_page_size | 0
| Tc_log_page_waits | 0
| Threads_cached | 3
| Threads_connected | 26
| Threads_created | 1761
| Threads_running | 4
| Uptime | 10254430
| Uptime_since_flush_status | 10254430