MacOS – Wired memory in activity monitor

Most of the difference was marked probably memory marked as inactive. Any app can still use this memory, so it's not marked as used by some process.
For more info about inactive memory, see this thread.

Wired memory usually makes up a much smaller portion. This is memory used by the OS; it isn't available to your apps.

For more info, see the Apple article Reading System Memory Usage in Activity Monitor.

From what I can tell, wired memory belongs to the kernel, the innermost core of Mac OS X. It's many layers removed from the icons in the menubar, which are just ordinary apps showing themselves in an odd way.

Wired memory is used for some of the core functions of the operating system—things like keeping track of all the applications on your system, or open files and network connections, or chunks of memory used by various drivers. The "page tables" that form a map of your system's memory are also stored in wired memory, and a system with more memory needs larger page tables. I suspect that the memory used by the integrated video chips in most Macs is wired as well, but I can't find anything that says that outright. In any case, much of this information is needed to manage and access memory, and so it can't itself be swapped out to disk!

To understand why, imagine an enormous library. Think of, for example, the Bodleian Library at the University of Oxford, which has eleven million printed items. There's no way you could possibly fit all that stuff into a single building—certainly not one in the middle of a university campus.

So instead, imagine that the librarians construct a vast warehouse. (The real Bodleian Library has about forty sub-libraries of various descriptions, plus storage for really rare books, but this is a thought experiment.) Most of the books are kept in the warehouse, but anything that's been used recently is kept in the library. If you show up at the library looking for a book, and it's in the stacks there, you can read it immediately. If not, ask a librarian and the book you want will be transported from the warehouse and given to you the next day.

The information in wired memory, then, would be things like the card catalog, keys to the book delivery trucks, and maps of the route to the warehouse. If you stored these things in the warehouse, you could never retrieve books to bring them back to the library—so they must be kept in the library at all times, lest the whole system break down.

Anyway, getting back to practical considerations: wired memory is basically used by your computer for internal bookkeeping of various sorts. You shouldn't worry about it.

And don't worry if you have lots of "inactive" memory and little "free" memory, either. Inactive memory is basically memory that Mac OS is keeping something in on the off chance it's needed again; if your system needs that memory for something else, it'll be converted to free memory without any performance hit.

To extend the library metaphor, imagine that the library keeps books that have been recently used in the stacks. The space is there in the stacks; there's no use leaving it empty, so you might as well keep the books you already have there. There's no harm in it, and sometimes someone will be able to pick up a book immediately that he would otherwise have had to wait for.

Similarly, inactive memory can only speed things up; it can't hurt your computer, so don't worry about it being too high.

Really, you shouldn't worry about your memory use unless wired + active starts getting close to the 8 GB in your computer. That's when you could get into trouble, because that's when Mac OS will start consuming disk space to add "extra" memory, damaging performance considerably.

Otherwise, you might as well have something in that memory. Ultimately, unused memory is just a waste of power—if you have it, you might as well put it to use.