MacOS – Disable shift key slow animations from command line

You can disable the keyboard shortcuts for slow-motion effects by following these instructions:

1. Open Terminal.

2. Open the plist file in your user's library preferences folder that contains the setting by typing open ~/Library/Preferences/com.apple.symbolichotkeys.plist and hit return.

3. A window similar to this will open in Xcode:

5. For items 34, 35, and 37, set enabled to NO.

6. Close the file, click Save if prompted, and restart your system.

7. Enjoy.

Note: 34 and 35 may not be present in the plist if you have never opened the Mission Control preferences pane and changed the "Mission Control" or "Application windows" settings. If 37 isn't present either, simply add it yourself.

This process has been tested with:

• OS X Yosemite
• OS X El Capitan
• macOS Sierra

Source

1. MacWorld
2. In Translation

To disable Notification Center from the command line, write a KeepAlive key that is false into the /System/Library/LaunchAgents/com.apple.notificationcenterui.plist like so:

sudo defaults write /System/Library/LaunchAgents/com.apple.notificationcenterui KeepAlive -bool false  

If you want to re-enable Notification Center, you’d just run the same with a true:

sudo defaults write /System/Library/LaunchAgents/com.apple.notificationcenterui KeepAlive -bool true  

Method to DISABLE without sudo:

launchctl unload -w /System/Library/LaunchAgents/com.apple.notificationcenterui.plist  
killall NotificationCenter

Method to ENABLE without sudo:

launchctl load -w /System/Library/LaunchAgents/com.apple.notificationcenterui.plist  

Then just hit Command+Shift+G and go to /System/Library/CoreServices/ then find “Notification Center” and double-click it to launch it again

Tutorial with useful info here and here