There shouldn't be a problem with this at all. Simply connect the devices and set them up as normal. I have an iPod, iPad, and several iPhones that sync with my Mac and I have not encountered any problems.
As far as using different email, contact, and sync info, you can set up all of that on the actual device itself in "Settings" > "Mail, Contacts, Calendars".
Syncing with iCloud
If you will be syncing email, contacts, and calendars using iCloud on each device, be sure to uncheck the following in the "Info" tab in iTunes:
-"Sync Address Book Contacts"
-"Sync iCal Calendars"
-"Sync Mail Accounts"
Syncing without iCloud, Using Sync Data from Your Mac
If you will be syncing email, contacts, and calendars using the info that is on your Mac, check off the following in the "Info" tab in iTunes, and then select which email account, contact list, and calendars you want to sync:
-"Sync Address Book Contacts"
-"Sync iCal Calendars"
-"Sync Mail Accounts"
Syncing Content from the iTunes Store
As far as syncing audio and video that was purchased from the iTunes Store, you will need to enter the proper account information on each device. This can be done in "Settings" > "Store". Changing the Apple ID in the "Store" settings will not affect the Apple ID used for iCloud.
This is what the official Apple documentation says:
Your Apple ID can have up to 10 devices and computers (combined)
associated with it. Each computer must also be authorized using the
same Apple ID. Once a device or computer is associated with your Apple
ID, you cannot associate that device or computer with another Apple ID
for 90 days. You can view which devices or computers are currently
associated, remove unused devices or computers, and see how long
before they can be associated with a different Apple ID from the
Account Information page in iTunes on your computer.
Last Modified: November 14, 2011
Best Answer
Not sure which iTunes version you have installed but as of 10.2, once I deleted an app from the app list in iTunes, the app is deleted from all iOS devices the next time they're connected and synced.