How do I turn off all notifications at once and then turn them back on later (like if friend is playing game?)
IOS – How to turn of all notifications at once on the iPhone 4S on 5.0.1
iosnotifications
Related Solutions
In Mountain Lion, this is done in the Notifications under System Preferences. Open System Preferences, select Notifications, choose Mail in the left pane, and then select "None".
Do Not Disturb will mute all notifications. You can enable it by opening Notification Center by clicking on the NC icon in the menubar (or sliding in from the side of the trackpad with two fingers) and turning the switch on.
You can permanently set Do Not Disturb on by going to System Preferences → Notifications and setting the schedule to "00:00 to 23:59".
→ 
To remove Notification Center altogether, you can run the following Terminal commands:
launchctl unload -w /System/Library/LaunchAgents/com.apple.notificationcenterui.plist
killall NotificationCenter
sudo defaults write /System/Library/LaunchAgents/com.apple.notificationcenterui KeepAlive -bool False
Make sure to scroll to copy the entire line
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Best Answer
If you just want to disable sounds, then you can flip the mute switch above the volume buttons. If you want to disable notifications that are based on an Internet connection (e.g. NYTimes, ESPN), you can put your iPhone in airplane mode which turns off wifi, 3G, and Bluetooth so you don't have an Internet connection. For apps that send notifications at a certain time (e.g. iCal reminders), there's no easy way to turn those off all at once other than turning them off individually in settings>notifications.