Most often USB flash drives on the market are pre-partitioned under (Windows) Master Boot Record.
Until El Capitan a special widget in Disk Utility made it possible to set the partition type to GUID.
In High Sierra there is a dedicated partition button, but it is greyed out. How can an alternative partition table be chosen?
Best Answer
In Disk Utility, near the close/minimize/fullscreen buttons, you can see a "View" mode dropdown menu. Set the view mode to "Show All Devices", then you'll see the "root" drives. Click on a root drive, and then click on the "Erase" button. Now an option to change the "Scheme" from Master Boot Record to GUID appears in the Erase subwindow.