How to automate changing the settings when you connect the mouse

Update 2020/12/03: As other's have pointed out, this is not a feature of Karabiner in newer versions.

It appears that this is integrated in the Karabiner app so it works out of the box without any custom XML (which are described above).

You'll need the following settings:

• Karabiner Preferences > Change Key > Karabiner core settings > Exclude devices > Don't remap Apple's pointing devices
• Karabiner Preferences > Change Key > Pointing Device > Reverse scrolling direction > Reverse Vertical Scrolling

Set the Enable Natural Scrolling setting in the Mouse/TrackPad PrefPane to 'enabled'. This allows for the internal trackpad to work as it's supposed to. Any connected non-Apple external mouse will scroll in their own natural way.

Based on the information provided I would say the mouse settings are not been loaded.

You can add the "MicrosoftMouseHelper" to the log in items area.

That should override the OS X defaults.

The file should be located in your /Library/PreferencePanes/Microsoft Mouse.PrefPane/Contents/Resources/MicrosoftMouseHelper